Buy Metacam For Cats
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Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is approved for cats as a one-time injection given before surgery to control pain and inflammation after spays, neuters, and orthopedic surgeries (like repairing a torn ligament or fixing a broken leg). Injectable meloxicam products are not approved for more than one dose (repeated doses) in cats in the United States. Oral meloxicam products, which come as an oral suspension and a transmucosal spray, are not approved for cats; they are only approved for dogs.
The boxed warning on most of these products states: Repeated use of meloxicam in cats has been associated with acute renal failure and death. Do not administer additional injectable or oral meloxicam to cats. See Contraindications, Warnings, and Precautions for detailed information.
The boxed warning on OroCAM® Transmucosal Spray is very similar and states: Repeated use of meloxicam in cats has been associated with acute renal failure and death. Do not administer meloxicam transmucosal oral spray to cats. See Contraindications for detailed information.
Meloxicam (brand names Metacam® Loxicom®, OroCAM®, Rheumocam) is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever in dogs and cats. It is indicated for the treatment of osteoarthritis in dogs and cats. Meloxicam is also used to treat pain associated with surgery.
Metacam® Oral Suspension for Cats (meloxicam) is indicated for the alleviation of inflammation and pain (1) following surgery such as onychectomy, ovariohysterectomy or castration, or (2) associated with acute, mild to moderate musculoskeletal disorders in cats.
Instructions for Use: Please carefully follow the instructions of the veterinarian. Particular care should be given with regard to the accuracy of dosing. Shake well before use. To be administered orally either mixed with food or directly into the mouth. The suspension can be given using the drop dispenser of the bottle for cats of any body weight (0.017 mg/drop). Alternatively and for cats with a body weight of at least 2 kg, the Metacam® Oral Suspension for Cats measuring syringe (provided in the package) can be used. Dosing procedure using the drop dispenser of the bottle:
Cautions: Particular care should be taken with regard to accuracy of dosing in cats. Do not exceed the stated dose. The accumulation of meloxicam occurs when an initial oral loading dose is given and followed by repeated oral dosing with Metacam® Oral Suspension for Cats.
The safety of Metacam has not been evaluated in breeding, pregnant or lactating cats. In case of overdosing, symptomatic treatment should be initiated. Increased risks of drug intolerance may occur in patients already debilitated. Avoid use in dehydrated, hypovolemic, or hypotensive cats because of increased risk of renal toxicity. Animals being treated with meloxicam should be monitored for the occurrence of adverse reactions, as susceptibility varies with the individual.
All cats should undergo a thorough history and physical examination before the initiation of an NSAID treatment. When possible, appropriate laboratory tests should be conducted to establish hematological and biochemical baseline data before the administration of any NSAID.
Renal and urinary: renal disorder, renal failure, urine abnormalities. Repeat dosing in cats at doses higher than currently recommended has been associated with acute renal failure and death.
Safety Studies: Studies on cats receiving meloxicam have demonstrated much higher sensitivity to NSAIDs than dogs. Cats receiving a subcutaneous dose of Metacam 0.5% Injection at 0.3 mg/kg or 0.6 mg/kg, followed by the same dose orally with Metacam 1.5 mg/mL Oral Suspension for 8 additional days (4 cats per group) had decreased appetites, acute gastrointestinal and circulatory disorders after day 7. Necropsy (day 9) confirmed treatment-related pyloric/duodenal ulceration and secondary peritonitis.
In a second study, cats received a subcutaneous dose of Metacam 0.5% Injection at 0.3 mg/kg or 0.6 mg/kg, followed by 0.1 or 0.2 mg/kg orally for 9 additional days (four cats per group). One cat in each group was clinically depressed on the last day of treatment. Duodenal ulceration and secondary peritonitis were observed at necropsy.
A third study evaluated 1X, 3X and 5X subcutaneous injections (0.3 mg/kg) for 3 consecutive days (6 cats per group). Histopathology demonstrated slight to minimal papillary necrosis in the kidneys and mucosal erosion in the 3X and 5X groups. No treatment related changes were noted in the 1X group.
A fourth target animal safety study was carried out using Metacam 0.5 mg/mL Oral Suspension for Cats. Adult cats (6 per group) received either placebo, 0.1 mg/kg day one followed by 0.05 mg/kg, 0.3 mg/kg day one followed by 0.15 mg/kg or 0.5 mg/kg day one followed by 0.25 mg/kg for 90 days. The only observed adverse reactions in the 1X group were vomiting and diarrhea in a single cat on five occasions on two separate days. The incidence of treatment-related gastrointestinal adverse reactions increased with increasing oral dosages and included vomiting, diarrhea and melenic feces. Evidence of gastrointestinal ulceration was apparent on histopathology in 1/6 cats in the 3X and 5X groups. The findings serve as a reminder of the sensitivity of cats to adverse reactions of NSAIDs and of the narrow therapeutic window of this group of drugs in the species.
A fifth tolerance study evaluated 14 days of treatment with either placebo, 0.025 (0.5X), 0.05 (1X) or 0.1 mg/kg (2X) the recommended dose (4 cats per group). No significant differences between groups were observed for any of the clinical, biochemical or pathological outcomes evaluated.
Efficacy clinical study for acute musculoskeletal disorders: The safety and clinical efficacy of Metacam® Oral Suspension for Cats (meloxicam) was evaluated in cats suffering from acute musculoskeletal disorders in a non-inferiority, positive-controlled, blinded, randomized, multi-centre field study.
In total, 120 cats (60 cats in each treatment group) were included in the study. Among the patients that completed the study, 54 cats were treated with Metacam® Oral Suspension for Cats at a dosage of 0.1 mg/kg once on the first day, followed by a dosage of 0.05 mg/kg once daily for the four following days, and 58 cats received the positive control drug at the approved dosage for 5 consecutive days.
Adverse events were reported for 3 cats treated with Metacam® Oral Suspension for Cats with none of these classified as probably related to the treatment. In the positive control group, adverse events were reported in 3 cats, including two classified as probably related to the treatment.
Metacam® Oral Suspension for Cats, at a starting dosage of 0.1 mg/kg once on the first day of treatment followed by a dosage of 0.05 mg/kg once daily for four consecutive days in cats suffering from acute musculoskeletal disorder, proved to be efficacious, safe and easy to administer.
Metacam is a prescription medication that is FDA approved for use in dogs. Metacam is available as 1.5mg/ml suspension in a 10 ml, 32 ml, 100 ml, or 180 ml plastic squeeze dropper bottle with a measuring dose syringe included in the package. Metacam is also available as 0.5mg/ml suspension in a 15 ml dropper bottle with a measuring dose syringe included in the package. The usual dose of Metacam in dogs is 0.1mg per pound as an initial dose the first day, followed by 0.05mg per pound once a day thereafter. Shake well before using Metacam. Contact the veterinarian if the pet has bloody, black or tarry stools, blood in vomit, swelling or rapid weight gain due to fluid retention, unusual fatigue or weakness, yellowing of the eyes, excessive itching, abdominal pain or tenderness as these symptoms could indicate serious side effects. Warning: Repeated use of meloxicam in cats has been associated with acute renal failure and death. Do not administer additional doses of injectable or oral meloxicam to cats. Before giving your pet any prescription or over the counter medications check with your veterinarian or pharmacist.
Metacam is a non-steroidal anti-inflammatory medicine suitable for certain animals, including cats and guinea pigs. Its active ingredient is meloxicam which is used to manage inflammatory pain. Metacam for Cats and Guinea Pigs is often prescribed after surgery to reduce pain and associated inflammation. Metacam Oral Suspension for Cats and Guinea Pigs is also used to manage inflammation associated with acute and chronic musculoskeletal disorders such as osteoarthritis.
Metacam Oral Suspension is a non-steroidal anti-inflammatory medicine suitable for certain animals, including cats and guinea pigs. Its active ingredient is meloxicam which is used to manage inflammatory pain. Metacam is often prescribed after orthopaedic and soft tissue surgery in cats to reduce pain and associated inflammation. 781b155fdc